No secondary metabolite regions were found in these records:
NC_015409.1 (Micromonospora maris AB-18-032)
Compact view
NC_015434 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 3 - NRPS,arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS: cds(Condensation and (AMP-binding or A-OX)) arylpolyene: (APE_KS1 or APE_KS2)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 495438 - 581354:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:
N/A
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
SAFHWGYVVK
Nearest Stachelhaus code(s):
Leu or Ile DAFFLGNVVK (32% 8Å match)
Stachelhaus code match:
60% (weak)
NC_015434 - Region 4 - NAGGN
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 5 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 2088583 - 2131402:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:
N/A
Single AA prediction:
glu (Glu)
Stachelhaus prediction details:
Stachelhaus sequence:
DSWDLGTIGK
Nearest Stachelhaus code(s):
Glu DVWHVGSIGK (53% 8Å match)
Asp DSWKLGVVDK (47% 8Å match)
Stachelhaus code match:
60% (weak)
NC_015434 - Region 6 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location <2555478 - 2625920:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
VAB18032_RS11755: mal
PKS_AT (550..838): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 95.8%
inactive: 79.2%
2-Rhyd-Malonyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 172.9
inactive: 94.0
Methoxymalonyl-CoA: 47.5
Methylmalonyl-CoA: 40.3
Isobutyryl-CoA: 32.1
Propionyl-CoA: 16.6
CHC-CoA: 9.2
Acetyl-CoA: 2.2
Benzoyl-CoA: 0.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -1.5
Ethylmalonyl-CoA: -3.3
VAB18032_RS11760: mmal - mmal
PKS_AT (573..845): mmal
ATSignature: Methylmalonyl-CoA
Top 3 matches:
Methylmalonyl-CoA: 100.0%
Methoxymalonyl-CoA: 95.8%
Ethylmalonyl-CoA: 91.7%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 200.3
Ethylmalonyl-CoA: 188.7
Methoxymalonyl-CoA: 171.2
2-Methylbutyryl-CoA: 140.8
trans-1,2-CPDA: 121.1
Propionyl-CoA: 113.4
Malonyl-CoA: 106.1
CHC-CoA: 95.7
Isobutyryl-CoA: 77.7
Acetyl-CoA: 61.6
Benzoyl-CoA: 52.4
3-Methylbutyryl-CoA: 46.5
fatty_acid: 39.9
inactive: 38.6
PKS_AT (2160..2445): mmal
ATSignature: Methylmalonyl-CoA
Top 3 matches:
Methylmalonyl-CoA: 100.0%
Methoxymalonyl-CoA: 95.8%
Ethylmalonyl-CoA: 91.7%
minowa: Methylmalonyl-CoA
Prediction, score:
Methylmalonyl-CoA: 195.4
Ethylmalonyl-CoA: 181.3
Methoxymalonyl-CoA: 158.2
trans-1,2-CPDA: 123.8
Malonyl-CoA: 105.8
2-Methylbutyryl-CoA: 103.7
Propionyl-CoA: 98.5
CHC-CoA: 86.3
Isobutyryl-CoA: 41.0
Benzoyl-CoA: 38.8
Acetyl-CoA: 38.4
3-Methylbutyryl-CoA: 36.3
inactive: 30.5
fatty_acid: 29.3
VAB18032_RS31665: mal - mal - mal - mal
PKS_AT (510..791): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 95.8%
inactive: 75.0%
2-Rhyd-Malonyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 194.2
inactive: 86.6
Methylmalonyl-CoA: 84.4
Methoxymalonyl-CoA: 82.1
Propionyl-CoA: 43.3
Ethylmalonyl-CoA: 37.1
Isobutyryl-CoA: 35.1
CHC-CoA: 34.7
2-Methylbutyryl-CoA: 26.2
Benzoyl-CoA: 25.6
Acetyl-CoA: 22.6
fatty_acid: 19.3
trans-1,2-CPDA: 15.2
3-Methylbutyryl-CoA: 5.9
PKS_AT (1477..1760): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 91.7%
inactive: 75.0%
2-Rhyd-Malonyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 165.1
inactive: 77.3
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 45.5
Propionyl-CoA: 22.9
Acetyl-CoA: 17.3
fatty_acid: 13.8
Ethylmalonyl-CoA: 11.9
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 9.4
Benzoyl-CoA: 9.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
PKS_AT (3061..3344): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 91.7%
inactive: 75.0%
2-Rhyd-Malonyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 165.1
inactive: 77.3
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 45.5
Propionyl-CoA: 22.9
Acetyl-CoA: 17.3
fatty_acid: 13.8
Ethylmalonyl-CoA: 11.9
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 9.4
Benzoyl-CoA: 9.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
PKS_AT (4661..4926): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 95.8%
inactive: 79.2%
2-Rhyd-Malonyl-CoA: 54.2%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 173.0
inactive: 82.7
Methoxymalonyl-CoA: 51.8
Methylmalonyl-CoA: 46.7
Propionyl-CoA: 23.7
Acetyl-CoA: 22.8
fatty_acid: 18.8
Isobutyryl-CoA: 16.3
Benzoyl-CoA: 14.7
CHC-CoA: 12.6
Ethylmalonyl-CoA: 9.1
trans-1,2-CPDA: 7.9
3-Methylbutyryl-CoA: 7.4
2-Methylbutyryl-CoA: 7.0
NC_015434 - Region 7 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 2712081 - 2778470:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
VAB18032_RS12385: mal - mal - mal
PKS_AT (540..830): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 83.3%
inactive: 66.7%
Propionyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 161.7
inactive: 53.4
Methoxymalonyl-CoA: 53.4
Methylmalonyl-CoA: 52.5
Isobutyryl-CoA: 16.2
Ethylmalonyl-CoA: 14.1
2-Methylbutyryl-CoA: 13.3
Benzoyl-CoA: 12.1
Propionyl-CoA: 10.9
CHC-CoA: 9.7
Acetyl-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
PKS_AT (1532..1819): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 91.7%
inactive: 75.0%
Methylmalonyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 157.1
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 60.2
inactive: 59.4
Ethylmalonyl-CoA: 31.7
CHC-CoA: 22.4
fatty_acid: 21.3
Propionyl-CoA: 19.7
Isobutyryl-CoA: 18.0
Acetyl-CoA: 16.9
Benzoyl-CoA: 13.9
trans-1,2-CPDA: 10.4
2-Methylbutyryl-CoA: 6.9
3-Methylbutyryl-CoA: 0.0
PKS_AT (3200..3496): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 95.8%
inactive: 83.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 185.5
inactive: 92.2
Methoxymalonyl-CoA: 55.4
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 32.5
Isobutyryl-CoA: 28.6
2-Methylbutyryl-CoA: 26.9
Ethylmalonyl-CoA: 19.4
CHC-CoA: 14.8
trans-1,2-CPDA: 10.6
Acetyl-CoA: 9.5
Benzoyl-CoA: 9.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
VAB18032_RS32600: mal - mal
PKS_AT (562..826): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 83.3%
inactive: 70.8%
Propionyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 164.8
inactive: 82.6
Methoxymalonyl-CoA: 60.1
Methylmalonyl-CoA: 53.6
Propionyl-CoA: 32.8
Isobutyryl-CoA: 27.9
Benzoyl-CoA: 27.5
fatty_acid: 20.2
Ethylmalonyl-CoA: 19.7
Acetyl-CoA: 17.8
trans-1,2-CPDA: 16.6
CHC-CoA: 15.6
2-Methylbutyryl-CoA: 9.4
3-Methylbutyryl-CoA: 4.5
PKS_AT (2205..2479): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 83.3%
inactive: 70.8%
Propionyl-CoA: 58.3%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 166.0
inactive: 80.6
Methoxymalonyl-CoA: 62.5
Methylmalonyl-CoA: 58.8
Propionyl-CoA: 37.6
Isobutyryl-CoA: 30.7
Benzoyl-CoA: 28.0
Ethylmalonyl-CoA: 24.4
Acetyl-CoA: 21.5
trans-1,2-CPDA: 21.2
fatty_acid: 19.3
CHC-CoA: 15.2
2-Methylbutyryl-CoA: 10.0
3-Methylbutyryl-CoA: 1.7
VAB18032_RS12395: mal
PKS_AT (552..842): mal
ATSignature: Malonyl-CoA
Top 3 matches:
Malonyl-CoA: 87.5%
inactive: 75.0%
minowa: Malonyl-CoA
Prediction, score:
Malonyl-CoA: 197.0
inactive: 95.7
Methoxymalonyl-CoA: 74.5
Methylmalonyl-CoA: 55.0
Ethylmalonyl-CoA: 28.3
Propionyl-CoA: 26.2
Isobutyryl-CoA: 24.0
fatty_acid: 19.5
Benzoyl-CoA: 16.5
Acetyl-CoA: 15.6
trans-1,2-CPDA: 12.5
2-Methylbutyryl-CoA: 12.5
CHC-CoA: 7.3
3-Methylbutyryl-CoA: 0.0
NC_015434 - Region 8 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 9 - NRPS,T1PKS,T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
T2PKS: (t2ks and t2clf) NRPS: cds(Condensation and (AMP-binding or A-OX)) T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Type II PKS
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 2950466 - 3098928:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Predictions of starter units, elongations, product classes, and potential molecular weights for type II PKS clusters. More detailed information is available here.
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 16, location 3198127 - 3246920:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
NC_015434 - Region 11 - LAP,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or TIGR03602) and not cyanobactin_synth) lanthipeptide-class-ii: cds(LANC_like and DUF4135)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme. Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
VAB18032_RS15325 - Class II
Cleavage pHMM score: -3.30
RODEO score: 0
Monoisotopic mass: 3742.8 Da
Molecular weight: 3745.3 Da
Number of bridges: 3
Additional modifications: OH
Alternative weights
(assuming N unmodified Ser/Thr residues)
3763.3 Da N = 1
NC_015434 - Region 12 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 13 - LAP,terpene,thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5) thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton) LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or TIGR03602) and not cyanobactin_synth)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Thiopeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
No matches found.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present. Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NC_015434 - Region 14 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX)) NRPS: cds(Condensation and (AMP-binding or A-OX))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 24, location 3897112 - 3991157:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
VAB18032_RS17340: X
AMP-binding (179..582): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr
Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:
ser (Ser)
Single AA prediction:
ser (Ser)
Stachelhaus prediction details:
Stachelhaus sequence:
DVPHFSLVEK
Nearest Stachelhaus code(s):
Ser DVPHFSLIEK (79% 8Å match)
Stachelhaus code match:
90% (moderate)
NC_015434 - Region 15 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme. Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
VAB18032_RS17930 - Class III
Cleavage pHMM score: 8.60
RODEO score: 0
Monoisotopic mass: 1574.8 Da
Molecular weight: 1575.8 Da
Number of bridges: 2
Alternative weights
(assuming N unmodified Ser/Thr residues)
1593.8 Da N = 1
1611.8 Da N = 2
1629.8 Da N = 3
1647.9 Da N = 4
NC_015434 - Region 16 - T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
NRPS/PKS monomers
Type II PKS
NRPS/PKS monomer predictions
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
Type II PKS gene cluster prediction details
Predictions of starter units, elongations, product classes, and potential molecular weights for type II PKS clusters. More detailed information is available here.
NC_015434 - Region 17 - NRPS,T1PKS,thioamide-NRP,thioamitides
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
thioamitides: ((YcaO or TIGR03604) and TfuA) T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) NRPS: cds(Condensation and (AMP-binding or A-OX)) thioamide-NRP: (ATP-grasp and AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC))
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 30, location 4468659 - 4580902:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
VAB18032_RS32945: X
AMP-binding (10..391): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr
Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:
N/A
Stachelhaus prediction details:
Stachelhaus sequence:
DSYYWGSFAK
Nearest Stachelhaus code(s):
Stachelhaus code match:
0% (weak)
NC_015434 - Region 18 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 19 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
Legend:
core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NC_015434 - Region 20 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key. More detailed help is available here.
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
ClusterBlast
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region. Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection. Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features
Identifier
Product
Length
Function
Sequence
NCBI Blast
Filter details
NT
AA
NT
AA
No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details. A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar gene clusters
Shows regions from the antiSMASH database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the antiSMASH database (if applicable).
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region. Click on an accession to open that entry in the MiBIG database.
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship. Click on reference genes to show details of similarities to genes within the current region.
No matches found.
NRPS/PKS monomers
NRPS/PKS monomer predictions
Shows the predicted monomers for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
reset view
zoom to selection